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Treatment resistant depression - what finally helped you?

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Livebythesea

Well-known member
Joined
Nov 29, 2019
Messages
54
Location
East Coast
Does anyone have treatment resistant depression? Meaning no medication has helped you. If so, can you advise what has helped you to finally get out of the hole?
 
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JCPraha

Well-known member
Joined
Aug 27, 2018
Messages
513
I have TRD. My meds stopped working for me. I am taking 150 mg Seroquel at night and Trintellix in the morning. It helps. Transcranial Magnetic Stimulation (TMS) is another option I am considering. It is not easy when most meds fail to work. Very frustrating.
 
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Darkandmagicalme

New member
Joined
Nov 19, 2019
Messages
3
Location
Walsall
Hi,
I just came across your post about treatment resistant depression.
I am unable to take medication for my depression. Either the medication simply hasn't worked at all or I haven't been able to tolerate the side affects. Its been a struggle but I found talking therapy helped after awhile. Months and months of talking therapy. Mindfulness really helps me and yoga. But although difficult and sometimes a painful journey learning to be self aware was the key for me. Sorry there is no quick fix. Hope you find whatever works for you
 
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JCPraha

Well-known member
Joined
Aug 27, 2018
Messages
513
If some type of cognitive behavioral therapy helps, then that is the best remedy. Of course everything varies between individuals. If the root cause is an organic imbalance, then meds are often helpful. It is such a complicated and poorly understood disorder, and so much variance between individuals, so one size definitely does not fit all. As was mentioned, quick fixes are difficult to come by with this disorder.
 
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Marianda

Well-known member
Joined
Nov 18, 2019
Messages
48
Location
South America
Does anyone have treatment resistant depression? Meaning no medication has helped you. If so, can you advise what has helped you to finally get out of the hole?
The first time I took antidepressants they worked really well. Right now, nothing seems to work for me. I've been taking antidepressants for too long. My body knows all the tricks to not let them work. I continue with escitalopram which causes me terrible swelling after I walk. I also rely on alprazolam, which is a magic bullet for me. It fixes my worst thoughts is minutes.
 
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Darknesssdaughter

Well-known member
Joined
Nov 2, 2019
Messages
170
Location
Italy
Hi, I heard about Ketamine being used in treatment resistant depression and in anxiety.
 
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JCPraha

Well-known member
Joined
Aug 27, 2018
Messages
513
I have had a similar experience to Mirianda. Antidepressants worked well for me for quite some time but stopped working. I suppose the body adapts, like she said. It makes treatment quite difficult. Ketamine is being used with very good success in many cases. I haven't tried it yet, but I should. It is new and access to it is not so easy. It works much more rapidly then other types of meds. It is given IV and there is a formulation that is a nasal spray. If anyone tries it, I would love to know their experience with it.
 
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Livebythesea

Well-known member
Joined
Nov 29, 2019
Messages
54
Location
East Coast
I have had a similar experience to Mirianda. Antidepressants worked well for me for quite some time but stopped working. I suppose the body adapts, like she said. It makes treatment quite difficult. Ketamine is being used with very good success in many cases. I haven't tried it yet, but I should. It is new and access to it is not so easy. It works much more rapidly then other types of meds. It is given IV and there is a formulation that is a nasal spray. If anyone tries it, I would love to know their experience with it.
Thank you. I would love to know their experience too...and unfortunately at least in the US I think it is expensive at this point.
 
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JCPraha

Well-known member
Joined
Aug 27, 2018
Messages
513
I know, getting healthcare in the U.S. can be a nightmare. A lot of things are very expensive, including the health insurance itself. I guess it's better to not work and go on Medicaid.
 
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