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Treatment Resistant Depression - Brintellix

J

JCPraha

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Joined
Aug 27, 2018
Messages
515
have taken a number of anti-depressants over the years. Paxil, Zoloft, Cymbalta, Buproprion, Mirtazapine to name a few. They worked for many years but stopped working.

I now take Brintelix or I think Trintellix in the US. It helps somewhat, but my depression is far from resolved. I also take Mirtazapine at night, mostly to help with sleeping.

I think some people add a an anti-psychotic for treatment resistant depression, like Seroquel or Ablifiy.

Does anyone have any experience with treatment resistant depression and what combination of meds were helpful?
 
Jef Costello

Jef Costello

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May 11, 2019
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Seroquel or Abilify doesn't really do much for depression unless there are other diagnosises like schizophrenia, bipolar etc. Won't cure you from depression, that's for sure. It just takes the edge off and makes you apathic, tired and unable to feel anything really.. Maybe a TCA AD could be something to look at instead.
 
P

Pollypop

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Jul 23, 2015
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Location
England. Derbyshire
Hi JCPraha,
I didn’t realise you had treatment resistant depression.
(Or are you just asking about it)

I have been officially diagnosed with it, along with other things.
I feel as if I have taken the A to Z of medication.

At the moment I am on Lamotragine, Duloxatine and Mirtazapine.

Occasionally Temazepam and Diazepam.
Only prescribed 10 each month.

i sometimes feel frustrated and wonder why they are treating ‘treatment resistant’
depression!!
 
J

JCPraha

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Joined
Aug 27, 2018
Messages
515
Hello Pollypop,

Yes, I have treatment resistant depression. Many medications worked in the past but they stopped working. I have been on all the meds you are taking now. Duloxatine worked for me for one year then stopped working. Mirtazapine was helpful for sleep. I also take an occasional benzodiazepine (Xanax).

I tried Lamotragine but it really made me confused and dizzy, so I stopped taking it. But perhaps it is helpful for you. Everyone reacts differently, so it is really trial and error.

I am now taking Brintellix and I started taking Seroquel, which so far seems to help somewhat. I was thinking about trying ECT (electric shock therapy). Anything that can help with the severe depression is worth a try for me, since it is really miserable to live with.
 
P

Pollypop

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Jul 23, 2015
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Location
England. Derbyshire
I was given Lamotragine in the late 80’s.
It was only just being highlighted as a mood stabiliser.
I’m sure you know it was originally only used as anticonvulsant.

I’d been on 400mg daily. 200 morning and night until 2 yrs ago.
I never questioned it. Just kept on it with every psychiatrist I saw.

My CMHT became so disgraceful and incompetent that i withdrew
all contact.

Another very long story.

I saw a private psychiatrist who slowly reduced Lamotragine.200mg at the
moment, with the other meds.

After over 30 years Of different SSRI’s he immediately realised they
didn’t help me.

My mum had etc in the 70’s
I’ve also read about Transcranial Magnetic Stimulation but don’t know
anyone who has had it.
Also EMDR has been mentioned.

Sorry, I’ve got carried away and and totally disorganised the thread.
Best Wishes
 
G

Girl interupted

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Nov 17, 2018
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1,420
Low dose Prozac in the morning, 50mgs seroquel at night.
 
sadpunchingbag

sadpunchingbag

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May 29, 2019
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Location
London
May I ask for your diagnosis? Before I comment ? Is it general depression
 
J

JCPraha

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Joined
Aug 27, 2018
Messages
515
I have had generalized depression for years. It has become treatment resistant so hence it is now treatment resistant depression.
 
fazza

fazza

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Jul 23, 2014
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1,855
Location
U.K
Have a look at Latuda (lurasidone) its an ant psychotic but it is also great for depression.
I have struggled with depression for years combined with schizophrenia. The doctors considered a diagnosis of schizoaffective but at the moment I have schizophrenia with recurrent depression.

I was switched to Latuda. Within 3 weeks my depression was gone and my voices well under control.
 
J

JCPraha

Well-known member
Joined
Aug 27, 2018
Messages
515
Thank you. I am happy it helps you. I will look into trying Latuda, perhaps it can help me too. Right now I have been trying Seroquel along with Brintellix, it seems to help somewhat, but still not so great. I have mood swings. Some days are better than others. But at least it helps me sleep. But generally, I'm still struggling.
 
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