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The effect of lifetime adversities on resistance to antipsychotic treatment in schizophrenia patients

F

firemonkee57

Well-known member
Joined
Mar 23, 2009
Messages
8,224
The effect of lifetime adversities on resistance to antipsychotic treatment in schizophrenia patients

Abstract
Aim

The aim of this study is to examine whether there is an association between cumulative life adversities and treatment-resistant schizophrenia.
Methods

We recruited 186 participants diagnosed with schizophrenia spectrum disorders. Adverse life-events were assessed using the Stressful Life Events Screening Questionnaire (SLESQ) and the Childhood Trauma Questionnaire (CTQ). Treatment resistant status was identified using the criteria of the American Psychiatric Association for refractory schizophrenia. We performed a multiple logistic regression model, including life adversities, to predict the treatment resistant status controlling for confounding variables.
Results

Forty two percent of the patients were found to be treatment resistant (n = 78) and 58% were non-treatment resistant (n = 108). The treatment resistant group had higher score on both SLESQ and CTQ (4.5 ± 3.3 and 54.7 ± 19.7) than the non-treatment resistant group (2.5 ± 2.3 and 47.7 ± 17.5) and the difference between the two groups was significant for both SLESQ (p < 0.001) and CTQ (p = 0.011). After adjustment for demographic variables and previously reported risk factors of treatment resistance, the association remained significant for SLESQ (OR = 1.20, 95% CI 1.05–1.38; p = 0.009) but not for CTQ (p = 0.13).
Discussion

The results suggest that cumulative lifetime adversities could have an independent effect on the resistance to treatment in schizophrenia spectrum disorders. Routine assessment of trauma exposures and an individualized bio-psycho-social formulation is necessary for a personalized treatment.

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BillFish

BillFish

Well-known member
Joined
Sep 12, 2009
Messages
2,388
Abstract
Aim

The aim of this study is to examine whether there is an association between cumulative life adversities and treatment-resistant schizophrenia.
Methods

We recruited 186 participants diagnosed with schizophrenia spectrum disorders. Adverse life-events were assessed using the Stressful Life Events Screening Questionnaire (SLESQ) and the Childhood Trauma Questionnaire (CTQ). Treatment resistant status was identified using the criteria of the American Psychiatric Association for refractory schizophrenia. We performed a multiple logistic regression model, including life adversities, to predict the treatment resistant status controlling for confounding variables.
Results

Forty two percent of the patients were found to be treatment resistant (n = 78) and 58% were non-treatment resistant (n = 108). The treatment resistant group had higher score on both SLESQ and CTQ (4.5 ± 3.3 and 54.7 ± 19.7) than the non-treatment resistant group (2.5 ± 2.3 and 47.7 ± 17.5) and the difference between the two groups was significant for both SLESQ (p < 0.001) and CTQ (p = 0.011). After adjustment for demographic variables and previously reported risk factors of treatment resistance, the association remained significant for SLESQ (OR = 1.20, 95% CI 1.05–1.38; p = 0.009) but not for CTQ (p = 0.13).
Discussion

The results suggest that cumulative lifetime adversities could have an independent effect on the resistance to treatment in schizophrenia spectrum disorders. Routine assessment of trauma exposures and an individualized bio-psycho-social formulation is necessary for a personalized treatment.

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Said it a few times before, if the problem isn't a delusion and is very real, meds wont take the stress or the problem away.
 
R

ramboghettouk

Well-known member
Founding Member
Joined
Jan 7, 2008
Messages
16,739
Location
london
Said it a few times before, if the problem isn't a delusion and is very real, meds wont take the stress or the problem away.
but meds can calm you down enough that you don't attack a policeman and as a result keep you out of jail
 
S

supergreysmoke

Guest
but meds can calm you down enough that you don't attack a policeman and as a result keep you out of jail
Meds can make you docile enough for the policeman to attack you and still throw you in jail. You believe in the honest copper fallacy?
 
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