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Neuroleptics/Antipsychotics cause brain shrinkage

T

Truthometer

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The evidence that antipsychotics cause brain damage is piling up, while the psychiatric research community finds its own results hard to swallow.
I willl be presenting some of that evidence here:

1. Antipsychotics and Brain Shrinkage:
An Update


2. Antipsychotics and Brain Damage: Shrinkage & Volume Loss


Antipsychotics are drugs that alleviate symptoms of schizophrenia and psychotic episodes. These medications are considered highly effective interventions for mitigating “positive symptoms” such as hallucinations (e.g. hearing voices) and various types of delusions (e.g. assuming others are plotting against you). Approved uses for antipsychotics include treating individuals diagnosed with schizophrenia, bipolar disorder, and cases of drug-induced psychosis.

Most antipsychotics primarily function by acting as dopamine receptor (D2) antagonists. This means they bind to the dopamine receptors and prevent stimulation from misfiring or abnormally high dopamine concentrations. By inhibiting excess dopaminergic stimulation, the hallucinations and delusions that once plagued the individual begin to subside.

Despite the fact that psychotic symptoms are controlled by antipsychotics, those undergoing treatment often experience an array of damning side effects, including: severe weight gain, sexual dysfunction, hormonal imbalances, and in some cases diabetes. To make things worse, there is evidence that using antipsychotics may cause brain damage, especially when used over a long-term.

3. How Antipsychotics Cause Brain Damage
There are several ways in which antipsychotics are thought to cause brain damage. The brain damage associated with antipsychotic usage may directly influence the severity of cognitive symptoms of schizophrenia. Many users of antipsychotics experience cognitive deficits that are thought to be solely from their illness, when in reality they may be a result of the meds.

Prefrontal connectivity reductions: There is evidence derived from resting fMRI studies suggesting that connections in the prefrontal region of the brain are reduced as a result of antipsychotic treatment. A reduced number of connections may translate to reductions in complex thinking, planning, attention, emotional regulation, and memory.

Global brain volume loss: Studies have noted that antipsychotics reduce global brain volume. This means that a person’s brain with schizophrenia who has undergone years of antipsychotic treatment (especially at high doses), may display signs of neurodegeneration. Reductions in global brain volume means that nearly every aspect of brain functioning has potential to become impaired.

Grey matter volume loss: Grey matter is known to include various regions of the brain responsible for sensory perception, emotions, self-control, speech, decision making, and muscle control. Individuals taking antipsychotics experience reductions in grey matter volume, making it tougher to perform certain functions.

White matter volume loss: White matter is tissue that allows your brain to communicate with the central nervous system. It is comprised of myelin and axons, both of which facilitate chemical messages within the brain. Since those taking antipsychotics experience reductions in white matter, the communication system within their brain becomes impaired.

Source: Psychiatry Online
 
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Anime-Alchemy

Anime-Alchemy

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Thank you for this. Is there evidence for the same thing happening with other medications such as SSRI's? or SNRI's?
 
T

Truthometer

Active member
Joined
Dec 20, 2016
Messages
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Antidepressants do not cause brain shrinkage.

Thank you for this. Is there evidence for the same thing happening with other medications such as SSRI's? or SNRI's?
No, they cause the hippocampus to grow.
SSRI's and SNRI's do not cause brain shrinkage.
 
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