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Mirtazipane....how long?

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Jonny7

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Hello, i'm suffering again from GAD after 16 years remission where Sertraline worked like a dream. My 200mg Sertraline pooped out and GP has recommended Mirtzapine as a combination as opposed to going higher on Sertraline.

I've been on Mirtzapine for around 3 weeks and recently increased to 30mg as was getting sleep but after initially feeling better the anxiety is back again.

Wondering how long to hang on before going back to see GP?:low::low::low:
 
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Jonny7

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any advice out there please?
 
write

write

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Hi, do go back and see GP if you're struggling/things are getting worse, will help them work out what's best for you I hope. Can take many more weeks for things to settle but you shouldn't have to suffer more in the meantime x
 
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Jonny7

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Got an appointment for Friday now. Thank you
 
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mikl_pls

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Mirtazapine can be activating in the higher doses because it becomes more noradrenergic via antagonism of the presynaptic α2A autoreceptors. This might be why your anxiety got worse when you went up to 30 mg. You may discuss this with your doctor and try staying at 15 mg. At this dose it primarily acts as an antihistamine.
 
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Jonny7

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Thanks Mikl. I appear to have turned the corner and starting to feel much better so the 30mg is kicking in now. I had a lightbulb moment when my mood lifted and the anxiety disappeared. I’ve been symptom free for 2 days. Not getting carried away but hope for better times is restored for now :)
 
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mikl_pls

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Thanks Mikl. I appear to have turned the corner and starting to feel much better so the 30mg is kicking in now. I had a lightbulb moment when my mood lifted and the anxiety disappeared. I’ve been symptom free for 2 days. Not getting carried away but hope for better times is restored for now :)
That's great to hear! I wish you the best and hope it continues to work for you!

Just watch out for weight gain though... Mirtazapine will put some pounds on ya... That's just one of the downsides of that med. Other than that, for those for whom it works, it works!
 
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Jonny7

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That's great to hear! I wish you the best and hope it continues to work for you!

Just watch out for weight gain though... Mirtazapine will put some pounds on ya... That's just one of the downsides of that med. Other than that, for those for whom it works, it works!
 
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Jonny7

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Yes. I’m eating lots of fruit instead of carbs and doing plenty of exercise. Definitely more hungry than usual :)
 
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Jellybelly

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Dec 10, 2018
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Hello, i'm suffering again from GAD after 16 years remission where Sertraline worked like a dream. My 200mg Sertraline pooped out and GP has recommended Mirtzapine as a combination as opposed to going higher on Sertraline.

I've been on Mirtzapine for around 3 weeks and recently increased to 30mg as was getting sleep but after initially feeling better the anxiety is back again.

Wondering how long to hang on before going back to see GP?:low::low::low:
I have been on Mirtazapine for 2 years, 30mg. It doesn't do anything for my anxiety or depression but I continue taking it since it seems to help me with my insomnia and maintaining my weight (since I struggle being underweight).
 
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Jonny7

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Mirtazipane

5 weeks into Mirtazipane in total and 3 weeks on 30mg and the anxiety/depression not lifted after initially feeling better. Wondering how long to wait until trying 45mg?
 
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Jellybelly

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5 weeks into Mirtazipane in total and 3 weeks on 30mg and the anxiety/depression not lifted after initially feeling better. Wondering how long to wait until trying 45mg?
I think you should take it slow if your body is sensitive like mine. When I first started Mirt, I kept readjusting the dosage. 7.5mg to 15mg to 22.5mg to 30mg to 45mg then back to 30mg. It made me dizzy and anxious every time I adjusted. I know what you mean with that "initial good feeling." I remember feeling energized and motivated going from 30mg to 45mg. Eventually that feeling went away and that's why I didn't see the reason to continue taking 45mg. At low doses (7.5-15mg), it made me really sleepy within 1-2 hours of taking it. These days at 30mg, I don't always feel sleepy.
 
calypso

calypso

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I've been on Mirtazepine for years at 45mg. I find it works well as an antidepressant for me. The weight gain is a problem though. I think I read that it works better at 30 mg for depression and it has a different effect at 45mg - but I could be wrong. It helps with sleep and that is the number one problem with many MH difficulties.

I think our bodies adjust to it and then we are better slightly but not cured. Medication is a tool not a cure. I found therapy with the meds helped immeasurably and I would advocate that to work alongside it.

Are there reasons you get anxious? Are there certain situations that make it worse? Just interested.
 
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Jonny7

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No triggers or patterns for anxiety. Sertraline cured me for 16 years so was hoping Mirtazipane would do too or at least get me some way there ;)
 
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Jellybelly

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Hi Calypso,

I'm not sure if your response is to me or Jonny7, but I'll answer your question just in case it's to me hehe. I'm just an anxious person on a regular basis. I had it since I was a child in elementary school. However, during the times I kept adjusting the doses, I noticed it amplified my anxiety. I assume it's the body chemistry going through changes. I get it a lot when I start a new SSRI medication. Starting Mirtazapine wasn't bad at all for me and that's why I continued with it. It's when I kept playing with the dosage I started feeling a little funky.

I gained a little over 10 lbs with Mirt. I have had bad appetite all my life so it was a huge change for me to feel so much hunger to the point it was hard to satisfy my stomach.. It was intense cravings during the first couple months of starting Mirt. I'm underweight so I welcome the weight gain but I didn't like feeling hungry all the time!! It was bed time and my body kept wanting to snack.
 
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