• Share. Be Supported. Recover.

    We are a friendly, safe community supporting each other's mental health. We are open 24 hours a day, 365 days a year.

medication and weight gain



Jun 17, 2008
east, england
hi everyone haven't been on here for a while . could do with some advise from anyone willing to give it with regards to tablets and weight gain.
i'm currently on 3 meds - 20mg citalopram daily, 50mg amitriptyline daily and 2.5mg olanzapine daily.
i suffer with severe depression with episodes of severe agitation/mania.
i've been on citalopram for several years and had no problems but since being on the amitriptyline and olanzapine i have put on loads of weight ( 4 stone gradually over 4 years )
i've seen various doctors and psychs some of which say the weight gain is attributed to the tablets - some say it's just coincidence.
i've read loads of stuff about olanzapine in particular causing weight gain - have other people found this ? i seem to be on quite a small dose so is it likely to just be the olanzapine or is it the amitriptyline as well ? ( i never had any weight gain when solely on citalopram )
my appetite has increased so much and i've read several things about olanzapine supressing something in the brain that tells you your full has anyone else read this ?
we have just started trying for a family and the dr's have advised me to come off the olanzapine which I am ok with but don't feel ready to come off the ami or citalopram but would maybe consider reducing the ami if this is likely to be causing the weight problems also.
sorry for the huge long post would love to hear from anyone in a similar situation thanks a lot :)


Well-known member
Founding Member
May 27, 2008
Hi there,

From my experience (backed up by my pdoc) the olanzapine is always responsible for weight gain. I told my pdoc that I'd put on weight (2 - 3 stone:scared:!!!!) and he said straight away that it was because of him prescribing olanzapine. Looking at other posts here there's a general concensus along these lines. Never heard of a specific reason though.


My consultant warned me from the word go about weight gain and olanzapine and even a few days can push the weight up. There is probably an abstract of a study somewhere on pub med re the weight gain and olanzapine link.


Oct 3, 2008
in my experience risperdal (though with other side effects) is better in these regards as is seroquel. on abilify i actually lost weight,but that drug was an absolute NIGHTMARE i was one of the first people my psych's tried it on and i had a horrible reaction.they didnt listen to me, they put me on 5mg i was okay, they put me on 10mg i found it hard to sleep,they upped it to 20mg and said after a few days id stabalise. well once i had 20mg i was awake for 96 hours..straight.


Well-known member
Jun 15, 2008
North West
Hi there,

I've previously been on both citalopram and amiriptyline, same doses as yo and didn't gain weight, so by process of elimintation I would say it was olanzapine. I've also read that it cuan cause weight gain and about surpressing the fullness chemical in your brain, whereas citalopram often causes decreased appetite.

I've been taking Depakote and Mirtazapine since Feb and have put on nearly two stone, so steer clear of those if you can.
Similar threads
Thread starter Title Forum Replies Date
E Medication weight gain... And lack of sex drive Depression Forum 3
L Out of date medication Depression Forum 5
W Medication side effects Depression Forum 7
L Medication and Memory Loss Depression Forum 17
L can anyone recommend medication ? Depression Forum 2
J Anyone on pain medication Depression Forum 2
T Depression and Anxiety - possibly triggered by medication Depression Forum 1
A Switched Medication after 25 years on Paxil. Depression Forum 10
SnowFairy00 Advice re medication - should I seek a second opinion? Depression Forum 8
V changing medication... wishing the pain to go away. Depression Forum 1
B Best medication for depression Depression Forum 11
P Medication intolerance...don't know what to do Depression Forum 12
J Depressed with a Phobia of taking Medication - Any help would be appreciated more than you'll ever know. Depression Forum 8
R Medication Depression Forum 1
L Medication question? Depression Forum 3
J Medication Problems Depression Forum 5
J anyone try magic mushrooms for there anxiety depression? or treatment besides medication? Depression Forum 10
A How Medication Works Depression Forum 7
Riah3 should I consider medication PLEASE HELP Depression Forum 10
S What are people doing for therapy and medication now? Depression Forum 5
K I’m confused and need to vent (should I take medication that’s being offered to me???) Depression Forum 6
S Medication Depression Forum 6
S What medication is good Depression Forum 2
E Scared of Medication Depression Forum 4
S Medication is confusing me Depression Forum 11
L Medication Help Depression Forum 7
C Medication Waiting Game Got Me Like...:( :( Depression Forum 8
B Anyone tried this medication? Depression Forum 4
L Medication for Depression? Depression Forum 1
L Anyone else tired of hearing 'can you try a different medication?' 'can you go for a walk?' etc - ugh Depression Forum 14
G Medication side effects Depression Forum 11
RueBea85 New medication...Trintellix Depression Forum 1
J Stopping Medication Depression Forum 1
J Change of medication Depression Forum 1
M Medication change, worried Depression Forum 5
N No longer on medication, feel myself slipping back again Depression Forum 1
P depression medication with less side effects opinions pls Depression Forum 4
W Medication beginning Depression Forum 3
M Medication change, worried. Depression Forum 3
S Medication Depression Forum 1
S Medication Depression Forum 2
S Changing Medication Depression Forum 1
P Medication experiences yes/noi Depression Forum 11
C Medication question Depression Forum 4
P Going back on medication Depression Forum 3
P ECT or medication? Depression Forum 3
P Medication isn't working? Depression Forum 3
S New to medication Depression Forum 2
S Do we REALLY need antipsychotic medication...? Depression Forum 14
S Depression plus anxiety, effect of different medication, need advice from psychiatrists in the forum Depression Forum 1

Similar threads