• Share. Be Supported. Recover.

    We are a friendly, safe community supporting each other's mental health. We are open 24 hours a day, 365 days a year.

Is schizophrenia associated with an increased risk of chronic kidney disease? A nationwide matched-cohort study



Well-known member
Mar 23, 2009
Is schizophrenia associated with an increased risk of chronic kidney disease? A nationwide matched-cohort study

Objective The impact of schizophrenia on vital diseases, such as chronic kidney disease (CKD), has not as yet been verified. This study aims to establish whether there is an association between schizophrenia and CKD.

Design A nationwide matched cohort study.

Setting Taiwan's National Health Insurance Research Database.

Participants A total of 2338 patients with schizophrenia, and 7014 controls without schizophrenia (1:3), matched cohort for sex, age group, geography, urbanisation and monthly income, between 1 January 2003 and 31 December 2007, based on the International Classifications of Disease Ninth Edition (ICD-9), Clinical Modification codes.

Primary and secondary outcome measures After making adjustments for confounding risk factors, a Cox proportional hazards model was used to compare the risk of developing CKD during a 3-year follow-up period from the index date.

Results Of the 2338-subject case cohort, 163 (6.97%) developed a CKD, as did 365 (5.20%) of the 7014 control participants. Cox proportional hazards regression analysis revealed that patients with schizophrenia were more likely to develop CKD (HR=1.36, 95% CI 1.13 to 1.63; p<0.001). After adjusting for gender, age group, hypertension, diabetes mellitus, hyperlipidaemia, heart disease and non-steroid anti-inflammatory drugs (NSAIDs) usage, the HR for patients with schizophrenia was 1.25 (95% CI 1.04 to 1.50; p<0.05). Neither typical nor atypical antipsychotics was associated an increased risk of CKD in patients with schizophrenia.

Conclusions The findings from this population-based retrospective cohort study suggest that schizophrenia is associated with a 25% increase in the risk of developing CKD within only a 3-year follow-up period.

Is schizophrenia associated with an increased risk of chronic kidney disease? A nationwide matched-cohort study -- Tzeng et al. 5 (1) -- BMJ Open


It could also read.

Is long term anti-psychotic use associated with an increased risk of chronic kidney disease? A nationwide matched-cohort study
Similar threads
Thread starter Title Forum Replies Date
F No Evidence That Schizophrenia Candidate Genes Are More Associated With Schizophrenia Than Noncandidate Genes. Schizophrenia Forum 1
cpuusage Is Schizophrenia Associated with Brain Volume Changes Independently of Medication? Schizophrenia Forum 3
F Schizophrenia is associated with excess multiple physical-health comorbidities but low levels of recorded cardiovascular disease in primary care Schizophrenia Forum 5
G Do we feel alone due to our Schizophrenia Schizophrenia Forum 13
E Is ASD a common comorbidity with schizophrenia/psychotic illnesses? Schizophrenia Forum 1
Wishbone How old were you when you were officially diagnosed with Schizophrenia? Schizophrenia Forum 25
BEASTMODEWARRIOR why do people think schizophrenia population are crazy or monsters im scared shitless Schizophrenia Forum 7
whyoverandover (was mirrorImage123) Abandoned with Schizophrenia Schizophrenia Forum 11
H Schizophrenia Schizophrenia Forum 2
Kygoldy Schizophrenia Schizophrenia Forum 3
LORD BURT You do not want to 'have' schizophrenia Schizophrenia Forum 24
lizzard123 any young people on here that also have schizophrenia?? Schizophrenia Forum 6
R Has anyone elses schizophrenia been activated by a conscious action you took in reality? Schizophrenia Forum 4
D Paranoid schizophrenia - laughing to yourself ? Schizophrenia Forum 5
M Afraid to disclose to the government I have schizophrenia Schizophrenia Forum 12
I Schizophrenia. Who really cares? Schizophrenia Forum 28
M schizophrenia is literally the WORST of all MH disorders Schizophrenia Forum 13
K Am I developing early stages of schizophrenia? Schizophrenia Forum 2
S Can the progression of schizophrenia be slowed down or delayed with treatment/medication? I need treatment right now. I also have anhedonia. Schizophrenia Forum 8
S Should I tell them I have mental illness/depression or schizophrenia? Schizophrenia Forum 15
O Schizophrenia or Someone from Above Schizophrenia Forum 1
P People with schizophrenia who work Schizophrenia Forum 20
L Nothing whatsoever to do with schizophrenia Schizophrenia Forum 17
nenexx I CANT LIVE LIKE THIS, IS THIS SCHIZOPHRENIA? or what HELP ME Schizophrenia Forum 18
O Is it Schizophrenia or is it Someone From Above? Schizophrenia Forum 9
slowturtle Paranoid Schizophrenia Schizophrenia Forum 1
L did your schizophrenia Schizophrenia Forum 22
L Does your schizophrenia Schizophrenia Forum 6
nenexx Is this schizophrenia? Schizophrenia Forum 16
C What if schizophrenia has something to do with your spirit/higher self/soul/subconscious mind? Schizophrenia Forum 19
M Is that a sign to get schizophrenia? Schizophrenia Forum 16
MissPink Has my boyfriend got Schizophrenia? Schizophrenia Forum 5
O Clozapine for Schizophrenia is Great Schizophrenia Forum 5
lifecangetbetter suggestions for a job with someone with schizophrenia Schizophrenia Forum 2
S My cousin has schizophrenia Schizophrenia Forum 11
S Schizophrenia and Spravato Schizophrenia Forum 6
veela Schizophrenia and work Schizophrenia Forum 12
P I am so confused (schizophrenia / schizoaffective/bipolar) Schizophrenia Forum 2
M Happy Productive life despite schizophrenia Schizophrenia Forum 1
M when to tell someone you are dating you have schizophrenia Schizophrenia Forum 7
T Schizophrenia vs anxiety induced psychosis Schizophrenia Forum 2
S Schizophrenia and adhd Schizophrenia Forum 3
H How did you first know you had schizophrenia? Schizophrenia Forum 3
BEASTMODEWARRIOR Schizophrenia: Stigma and Challenges Schizophrenia Forum 55
L autism and schizophrenia Schizophrenia Forum 2
Tawny Eastenders story line - Schizophrenia Schizophrenia Forum 25
S Could it be schizophrenia Schizophrenia Forum 13
BEASTMODEWARRIOR Guys i think i have unlock some super powers from schizophrenia idk? Schizophrenia Forum 12
Amelia2020 I think i might have Schizophrenia Schizophrenia Forum 2
B Dating someone with Schizophrenia Schizophrenia Forum 2

Similar threads