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Folic acid for depression: FolATED finds methylfolate is a better candidate for augmenting antidepressants



Well-known member
Mar 23, 2009
Folic acid for depression: FolATED finds methylfolate is a better candidate for augmenting antidepressants

Depression is a common condition, affecting hundreds of millions of people around the world and has become the leading cause of disability in Europe. Although incredibly prevalent, treatment for depression is not always effective, with only one third of patients achieving remission with antidepressants.

Folate may have a role in treating depression. Lower levels of folate have been found in individuals with depression and lower folate levels have been associated with poorer responses to antidepressants. Given that folate is essential for the production of serotonin and noradrenaline in the human brain, and antidepressants act to increase the amount of these neurotransmitters, folate may be beneficial in increasing the effectiveness of antidepressants.

Previous studies on supplementing with folic acid during treatment for antidepressants have produced contradictory results as to its effectiveness, but have also been poorly powered. The overall objective of the FolATED (Folate Augmentation of Treatment – Evaluation for Depression) study was to assess the clinical effectiveness and cost effectiveness of supplementing with folic acid during treatment with antidepressants for moderate to severe depression. FolATED also looked into whether baseline folate levels predicted response to antidepressant medication.
- See more at: Folic acid for depression: FolATED study


Well-known member
Aug 17, 2012
The West Country
Very interesting.
I do think that something that gets massively overlooked in people with depression is the chance that they may be seriously lacking in vitamins/minerals etc.

I know it's not folic acid, but I reckon a load of the population of Britain must be lacking in vitamin D (the sun's never out), which i'm sure i've read can contribute to feeling low.

Oh and I know people say that getting vitamins through a healthy diet is far better than popping a supplement, but if people for whatever reason can't commit to a healthy eating plan then surely it's better to prescribe supplements?
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