• Hi. It’s great to see you. Welcome!

    Our forum members are people, maybe like yourself, who experience mental health difficulties or who have had them at some point in their life. Amongst our membership there is a wealth of expertise that has been developed through having to deal with mental health issues.

    We are an actively moderated forum with a team of experienced moderators. We also have a specialist safety team that works extra hard to keep the forum safe for visitors and members.

    Register now to access many more features and forums!

Familial Aggregation and Heritability of Schizophrenia and Co-aggregation of Psychiatric Illnesses in Affected Families.

F

firemonkee57

Well-known member
Joined
Mar 23, 2009
Messages
8,217
Familial Aggregation and Heritability of Schizophrenia and Co-aggregation of Psychiatric Illnesses in Affected Families.

Abstract

Strong familial aggregation of schizophrenia has been reported but there is uncertainty concerning the degree of genetic contribution to the phenotypic variance of the disease. This study aimed to examine the familial aggregation and heritability of schizophrenia, and the relative risks (RRs) of other psychiatric diseases, in relatives of people with schizophrenia using the Taiwan National Health Insurance Database. The study population included individuals with affected first-degree or second-degree relatives identified from all beneficiaries (n = 23 422 955) registered in 2013. Diagnoses of schizophrenia made by psychiatrists were ascertained between January 1, 1996 and December 31, 2013. Having an affected co-twin, first-degree relative, second-degree relative, or spouse was associated with an adjusted RR (95% CI) of 37.86 (30.55-46.92), 6.30 (6.09-6.53), 2.44 (1.91-3.12), and 1.88 (1.64-2.15), respectively. Compared with the general population, individuals with one affected first-degree relative had a RR (95% CI) of 6.00 (5.79-6.22) and those with 2 or more had a RR (95% CI) of 14.66 (13.00-16.53) for schizophrenia. The accountability for the phenotypic variance of schizophrenia was 47.3% for genetic factors, 15.5% for shared environmental factors, and 37.2% for non-shared environmental factors. The RR (95% CI) in individuals with a first-degree relative with schizophrenia was 3.49 (3.34-3.64) for mood disorders and 3.91 (3.35-4.57) for delusional disorders. A family history of schizophrenia is therefore associated with a higher risk of developing schizophrenia, mood disorders, and delusional disorders. Heritability and environmental factors each account for half of the phenotypic variance of schizophrenia.

Familial Aggregation and Heritability of Schizophrenia and Co-aggregation of Psychiatric Illnesses in Affected Families. - PubMed - NCBI

Therefore ,if I am reading this correctly,according to this research it's slightly more down to environmental factors.
 
Poopy Doll

Poopy Doll

Well-known member
Joined
Jun 13, 2015
Messages
11,502
Location
Fort Lauderdale, Florida, USA
All I know is my schizophrenic illustrator is totally irrationally attached to his mother whom he spends all his weekends with going grocery shopping and such like a child. He's 26. He does everything to please her and he is undergoing ECT every month for 2 years now, to please her. He doesn't create friendships because he spends all his time with her. He confided to me that he is gay and wants a boyfriend so I told him to take the bus to the gay and lesbian center but he never did. He has had so much ECT that he repeats himself quite frequently in the same conversation. He use to hear voices but all the other stuff is environmental.
 
Top