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Duloxetine and Serequel XR combo for MDD

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Fallout2019

Member
Joined
Jul 5, 2019
Messages
5
Location
United Kingdom
Hi all,

9 weeks ago I began Cymbalta and Serequel XR for depression and I have felt little improvement in my mood. 1 week ago I went from 60mg to 80mg duloxetine daily, but I have consistently been taking the serequel XR at a 50mg dose for the duration of my treatment. My GP seems reluctant to up the dosage of the serequel at this point and I am confused as to why, as from what I have read online serequel XR begins to be effective as an adjunct to antidepressants at a 150mg dose, at which point it begins to inhibit the reuptake of norepinephrine. However, from my understanding Cymbalta is already a potent inhibitor of norepinephrine, so what possible antidepressant benefit am I getting from this combo? Is there some antidepressant synergy with my current two medications or not? My doctor seems to know about as little as me about these things, which is why I've come online to ask you guys instead! Has anyone had success with a similar combo of meds as mine? And can anyone here possibly attempt to explain the antidepressant efficacy of this combination of meds? I'm contemplating coming off the serequel entirely as I worry that it is possibly negating the effect of my Cymbalta by blocking serotonin and dopamine (I assume that at a 50mg dose it is highly unlikely that the serequel is blocking much serotonin or dopamine, if any at all, but I still worry).

The pharmacology of medications is so confusing! Would you guys suggest that I try coming off the serequel or possibly increasing it to 150 mg? (the alleged antidepressant dose). I'm also confused as to why my GP started me on BOTH medications at the same time, as it surely could have been possible that the Cymbalta might have worked on its own. Ugh. It's all so very confusing, If anyone can be of any help here at all then I'd appreciate any information and advice.

By the way, my GP currently refuses to refer me to a psychiatrist at this point as he says that my depression is not severe enough.

Thank you. Sending lots of love and hugs to you all.

Ryan.
 
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Yellowdiamond

Active member
Joined
Jan 16, 2019
Messages
44
Ive had seroquel. For me personally seroquel didnt work, i got it for sleep and SZ. I think at least zyprexa is being used for depression, which is an antipsychotic. I dont know why they are used, but they are used. Do cymbalta work for you?
 
F

Fallout2019

Member
Joined
Jul 5, 2019
Messages
5
Location
United Kingdom
Ive had seroquel. For me personally seroquel didnt work, i got it for sleep and SZ. I think at least zyprexa is being used for depression, which is an antipsychotic. I dont know why they are used, but they are used. Do cymbalta work for you?
Hi there yellowdiamond! I'm not sure if the Cymbalta is working for me at all or not, my mood hasn't really improved much. The problem is that I was started on Cymbalta and Serequel at the same time, so I have no idea which one of them is providing any benefit.
 
Y

Yellowdiamond

Active member
Joined
Jan 16, 2019
Messages
44
Im on a similar combo (zyprexa and antidepressant) my mood is Kinda stable. But in your case your put on This combo, so you have to think if The combo is working for you. If you dont get negative side effects, its no need to quit either. These medications are given all The time.
 
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