• Welcome! It’s great to see you. Our forum members are people, maybe like yourself, who experience mental health difficulties or who have had them at some point in their life.

    If you'd like to talk with people who know what it's like

Do negative symptoms of schizophrenia reduce over time?

T

thrill

Guest
Background. Negative symptoms are a core component of schizophrenia which can severely impact quality of life and functional outcomes. These symptoms are understood to be highly stable but this has not been tested in a meta-analysis, despite the wealth of longitudinal data available.

Method. A systematic review of the literature was conducted, with eligible studies pooled into a random-effects meta-analysis. Planned meta-regressions were conducted to evaluate the impact of factors known to induce secondary negative symptoms, in addition to other possible sources of heterogeneity.

Results. The main analysis included 89 samples from 41 studies, totalling 5944 participants. Negative symptoms were found to significantly reduce in all treatment interventions, including in placebo and treatment as usual conditions, with a medium effect size (ES) present across all study conditions (ES = 0.66, 95% confidence interval 0.56–0.77, I2 = 94.0%). In a multivariate meta-regression, only the type of scale used was found to significantly influence negative symptom change. No difference in outcome was found between studies that excluded patients with a high level of positive or depressive symptoms, compared to those that did not.

Conclusions. Negative symptoms were found to reduce in almost all schizophrenia outpatient samples. A reduction was found across all conditions, with effect sizes ranging from small to large depending upon the condition type. These findings challenge the convention that negative symptoms are highly stable and suggest that they may improve to a greater extent than what has previously been assumed.
Cambridge Journals Online - Psychological Medicine - Abstract - Do negative symptoms of schizophrenia change over time? A meta-analysis of longitudinal data
 
LORD BURT

LORD BURT

Well-known member
Joined
Jul 8, 2013
Messages
34,891
Location
Mordor
We all need a carrot to chase. Helps with motivation.
 
Kerome

Kerome

Well-known member
Joined
Sep 29, 2013
Messages
12,750
Location
Europe
That's interesting though. If they found out the mechanism by which the improvement happened they might even be able to speed it up. It wouldn't be a full cure but it might lead to something partial.
 
Top