- Sep 14, 2020
My wife has a prescription of Epival EC (enteric coated - this is the non-extended release one) 500mg daily. Epival EC should be the same as Depakote DR. Her instructions are to take two 250mg tablets at night before bed. I'm a bit confused because I thought for the enteric coated tablets, you should spread out your dose instead of taking it all in one shot (take one 250mg in the morning and one in the evening). I know that the extended release (ER) pill you can take all at once, but thought this is not recommended for the EC/DR pill. Could it be that the pharmacy has the wrong instructions? Or does it not really matter?