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Antidepressents

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ffleaderman24

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Jul 30, 2011
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If you are currently on a AD or a bit confused about how it works and what to expect from withdrawals then this thread is for you, hope you enjoy. Please share with us what AD you are currently taking and if it works for you and dosage, enjoy!

Maois,trycyclic,SSRI,SNRI all these term describe a different type of antidepressent. Maois and trycylic have been replaced by the more recent SSRI and SNRI antidepressents. So they require more focus in this thread. SSRI's or Selective serotonin reuptake inhibitor are believed to increase the extracellular level of the neurotransmitter serotonin by inhibiting its reuptake into the presynaptic cell, increasing the level of serotonin in the synaptic cleft available to bind to the postsynaptic receptor. It's not that complicated trust me, i will make it simpler to understand-The presynaptic cell is the sender of serotonin to the postsynaptic receptor which is the receiver. In the middle of these two is the cleft. When the presynaptic cell sends serotonin to the postsynaptic receptor some of the serotonin goes back to the sender without ever reaching the receiver. In a normal person the majority of serotonin always goes to the receiver, while in a depressed individual the majority of serotonin goes back to the sender. An SSRI blocks the serotonin from going back to the sender and it bounces of the antidepressent and goes straight to the receiver. So now the majority of serotonin is going to the receiver curing depression.

It's very important to know what the medication is doing for you and hope you understand this better. Some SSRI's are more potent than others e.g. Citalopram (Celexa) is the weakest SSRI. At the moment i am on Citalopram 30mg, the max dose is 60mg, i used to be on Fluoxetine 60mg, the max dose for that is 80mg. SSRI's have a good responce in people suffering depression about 59.3%.

There is one negative thing about SSRI's and that is SSRI discontinuation syndrome, when lowering a dose or quitting cold turkey you can expect-
Symptoms described as "brain zaps", "brain shocks," "brain shivers", "head shocks" or "cranial zings" are a withdrawal symptom experienced during discontinuation (or reduction of dose) of antidepressant drugs.The symptoms are widely variable in description and of unknown etiology common descriptions include dizziness, electric shock-like sensations, sweating, nausea, insomnia, tremor, confusion, nightmares and vertigo

The shorter the medication stays in your body the more severe withdrawal effects e.g. paxil. The longer the medication stays in your body the less severe the withdrawal effects are e.g.Fluoxetine.

But are SSRI's the best AD's? no that would be SNRI's, but what's the difference?, well SSRI's only stop the reuptake of Serotonin while SNRI's also stop the reuptake of Norepinephrin and serotonin. They have a responce rate of 63.6%. So are clinically more effective than SSRI's at treating depression. They also have discontinuation syndrome.

Hope that helped you understand AD's a bit better. Please share the AD you are currently taking and if it works for you, and the dosage. Thankyou:clap:
 
A

Ainsworth

Guest
ive been on afew, duluxotine was my last one and the only one that worked but the side effect are hell.
 
B

Bear1

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Aug 16, 2011
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Hello

I am currently taking Sertraline 150mg, which I have been taking since February. I have been off work since then and quit my job as needed sometime out, I was only off 8 weeks and kept getting hassled, so decided to leave.

I find that I have bad anxiety attacks, fearful of going out, self harm and suicidal thoughts. I have also been having therapy, so I think the combination of medication and therapy should help.

I was previously on Fluoxetine 20mg 3 years ago, but had really bad side effects.
 
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ffleaderman24

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Jul 30, 2011
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ive been on afew, duluxotine was my last one and the only one that worked but the side effect are hell.
That is a SNRI so i'm glad it worked for you, SNRI's work on Serotonin and norepinephrin and are more effective than SSRI's which only work on Serotonin.
 
F

ffleaderman24

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Jul 30, 2011
Messages
293
Hello

I am currently taking Sertraline 150mg, which I have been taking since February. I have been off work since then and quit my job as needed sometime out, I was only off 8 weeks and kept getting hassled, so decided to leave.

I find that I have bad anxiety attacks, fearful of going out, self harm and suicidal thoughts. I have also been having therapy, so I think the combination of medication and therapy should help.

I was previously on Fluoxetine 20mg 3 years ago, but had really bad side effects.
You should speak to your psychiatrist asap. Antidepressents are known to cause suicidal thoughts. You are on a high dose of Sertraline and if it's causing you anxiety you should ask for a milder Antidepressent such as Citalopram, that's what i did. Suicidal thoughts from AD's is a very serious side effect and should be discussed with your psych.
 
Z

ziggy4828

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Aug 11, 2011
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trying to get out of the forest
Once i was put on prosaz..cant remember the dose but it cause extreme insomnia. Then citalopram which caused me to end up hypomanic. Eventually they put me on venlofaxine..again cant remember the dose but it was high, i was on it along with a mood stabilizer and an anti psychotic. It worked very well except for the huge weight gain. Came off it a year ago, lost 3 and a 1/2 stone. Feels good to have one less tablet to take : )
 
TiredTina

TiredTina

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Hi ffleaderman

What i dont understand is if SNRIs work better than SSRIs then why dont gp's prescribe them instead? I didnt even know about SNRIs. Also i didnt know that citalopran was the weakest SSRI, what exactly does this mean - maybe that is has less chance of working? I started taking citalopran on monday - 40mg, so im yet to find out if it works for me.
 
tattedmommy

tattedmommy

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Aug 10, 2011
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North Carolina
In the past I've taken Celexa, Wellbutrin, and Prozac. Celexa worked for a depressive episode but due to insurance coverage I was taken off. Prozac sent me manic. I don't recall Wellbutrin working for me.

Now I take Sertraline (Zoloft) 50 mg as part of my regimen. Not sure if its working because I take 3 other meds. My doc leaves it alone because we're still tweaking my dosages and doesn't want another variable he has to figure out. I came to him on this drug. Ultimately he wants me off. Once I stabilize we'll do this.
 
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ffleaderman24

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Jul 30, 2011
Messages
293
Hi ffleaderman

What i dont understand is if SNRIs work better than SSRIs then why dont gp's prescribe them instead? I didnt even know about SNRIs. Also i didnt know that citalopran was the weakest SSRI, what exactly does this mean - maybe that is has less chance of working? I started taking citalopran on monday - 40mg, so im yet to find out if it works for me.
SNRI's are a relatively new medication compared to SSRI's, because of this some SNRI's are still in development. SNRI's will become more popular in the near future, but at the moment SSRI's are so widely available they are used more often. Citalopram would have less of an effect than more potent SSRI's, but it is still good for treating major depression. If it doesn't work i'm sure they will put you on a better med to fit your needs.
 
F

ffleaderman24

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Jul 30, 2011
Messages
293
In the past I've taken Celexa, Wellbutrin, and Prozac. Celexa worked for a depressive episode but due to insurance coverage I was taken off. Prozac sent me manic. I don't recall Wellbutrin working for me.

Now I take Sertraline (Zoloft) 50 mg as part of my regimen. Not sure if its working because I take 3 other meds. My doc leaves it alone because we're still tweaking my dosages and doesn't want another variable he has to figure out. I came to him on this drug. Ultimately he wants me off. Once I stabilize we'll do this.
50mg is the reccomended starting dose for Sertraline and if it needs to be raised then it will be. I hope it works for you!
 
Girl Interrupted

Girl Interrupted

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Feb 24, 2011
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Citalopram has nasty side effects even at a low dose, that was my personal experience of it. Never again would I even contemplate taking an SSRI. Every medication I have taken, including Dothiepine, Amitryptaline, and Fluoxetine have caused side effects which far out-weighed the benefits of biological interventions for me personally. However medication sensitivity is noted in those with CFS.

I am trialling Tazodone again hoping it works this time around.
 
pepecat

pepecat

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Seroxat gave me a really bad reaction a few years ago - i only took one pill and it was awful. I find citalopram is ok after a couple of weeks of side effects. Once i get used to the effects it's fine - i don't notice anything. I got on ok with venlafaxine as well, but it did make me constipated, so i refused to take it. Other than that it was ok.
 
TiredTina

TiredTina

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Ffleaderman - just wondered if you could tell me how long citalopram stays in your system. In other words if you were to stop taking it, how long would it be before all trace of the meds were gone? Just interested. Also if you are going to get side effects, how long after you start taking them would it take? Dont know if you can help or not. Tina x
 
angiebib1976

angiebib1976

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I've been on Dothiepin (gave me a 'thick, foggy head), Seroxat (sent me high as a kite), Prozac ( made me really sick all the time), Nefazodone ( the best in my opinion, didn't suffer any side effects), Citalopram ( hallucinations, anxiety, the runs, sickness, sweating) Mirtazipine ( couldn't stop eating) and currently on Sertraline 50mg and a mood stabiliser. No bad side effects as of yet, apart from the inability to eat - just no real appetite!!

Take Care

Angie
 
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