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Antidepressants won't work.



New member
Aug 22, 2018

I've tried three I think different meds for my depression and anxiety over the last year and none worked. First it was low dose citalopram, no effect. Increased dose twice over about six to eight weeks, no effect. Switched to venlafaxine, no effect even with increased doses. Came off them and took nothing for months. Switched to sertaline maybe four months later, no effect again after about 7 weeks.

Why have none worked? Could it be some other condition that antidepressants have no effect on?



Well-known member
Jan 4, 2013
Welcome to the forum
Sometimes you can need combination therapy i.e. Two different drugs. Or find the right drug for you, some people need higher doses.
Often therapy like counselling or CBT is needed as well.
Hope you feel better very soon.
Take care


:welcome: to the forum. Sorry they don't help you. I tried different anti depressants and therapy for 15 years and it wouldn't help at all, or it would start helping than stop or make me feel worse! It's like some people are cursed to be depressed! :cry2::mad: I hope something works for us! :hug:


Hello Lakers93!

It is a case of trial and error when it comes to professionals prescribing anti-depressants. There are so many to choose from, and it can take some time to find the right medication at a therapeutic dose for any individual. There are more that they can try other than the others you have listed and, as Mayflower mentioned above, it might be the case that they try a combination of different anti- depressants.

It can be a very difficult time when struggling day-to-day, being prescribed something then having to wait while it is upped and upped....hoping it will eventually provide some relief. If a medication is not working for you it is important to make sure you let the health professionals know. Also if you are wanting to stop taking any particular medication, it is important you discuss it with the person who prescribed it so that you can taper it off properly. Medical guidance is usually essential since stopping a medication quickly can often make depression much worse.

I hope that they find the right medication for you soon and you get some respite.