I suffer from anhedonia, i think its mainly due to the dopamine antagonism, its been a long time since ive felt any pleasure from anything, aripiprazole works well because its a partial inverse agonist and it doesnt completely switch off your dopamine system it finds a way of getting around it im not sure exactly how it works, Also 5HT-1a and a2 are important which is why i think seroquel worked well for me, i think the best combination is ariapiprazole and a noradrenaline uptake inhibitor or maybe a drug that releases noradrenaline which is basically D2, 5HT-1a and a2 (noradrenaline) the main problem is the dopamine system which is why im searching for a antipsychotic which doesnt work on dopamine.