Abilify (Aripriprazole) is a dopamine receptor partial agonist

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#1


Aripriprazole (Abilify) is a partial agonist on 5HT1A, D2, D3, and D4 and an antagonist on 5HT2A. Abilify does not raise prolactin levels as a dopamine antagonist would cause. Abilify partially activates dopamine D2 receptors with intrinsic activity of up to 60% on postsynaptic receptors and 75% on presynaptic receptors, the activation of which cause the presynaptic neuron to release less dopamine [1] Abilify is has 68% intrinsic activity on 5HT1A receptors, activation of this receptor causes dopamine release in the prefrontal cortex.
 
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#2
Abilify is a Partial Agonist

Abilify

D1 Antagonist
D2 Partial Agonist, 60%
D3 Partial Agonist
D4 Partial Agonist
D5 Antagonist
5HT1A Partial Agonist , 68%
5HT2A Antagonist
 
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#3
On presynaptic D2 receptors, the intrinsic activity of Abilify gets as high as 75%. On postynaptic receptors it acts more like an antagonist, with intrinsic activity anywhere from 30%. Abilify acts as a dopamine partil agonist on the D2-like subfamily of dopamine receptors: D2, D3, and D4. Abilify is thought to inhibit dopamine transmission where it is in excess and promote dopaminergic transmission where it is deficit.

Abilify is a 5HT1A partial agonist with 68% intrinsic activity; which causes dopamine to be released in the prefrontal cortex, potentially treating depression, and negative symptoms of schizophrenia as well as cognitive deficits seen in this illness.

Abilify is a 5HT2A antagonist, which causes dopamine release in the nigrostriatal pathway.
This is a signature for atypical antipsychotics, as most of them block 5HT2A as well as dopamine D2.
 
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Notaround713

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#4
I’m on ability and not too happy with my results but supposedly less side effects.