• Hi. It’s great to see you. Welcome!

    Our forum members are people, maybe like yourself, who experience mental health difficulties or who have had them at some point in their life. Amongst our membership there is a wealth of expertise that has been developed through having to deal with mental health issues.

    We are an actively moderated forum with a team of experienced moderators. We also have a specialist safety team that works extra hard to keep the forum safe for visitors and members.

    Register now to access many more features and forums!

Abilify and Cannabis - Cannot get high off weed any longer

T

Truthometer

Active member
Joined
Dec 20, 2016
Messages
35
I have been taking Abilify 400mg every 3 weeks for about 6 months now. which is roughly equivalent to 20 mg per day. Three to four months into the treatment I noticed that weed no longer gives me euphoria. Marijuanna has always been pleasurable for me, but Abilify completely kills my "high".

I have done some research on Abilify and neuroleptics in general. Abilify is a dopamine partial agonist, so it is a dopamine receptor blocker, but partially activates these receptors at the same time. Functionally, Abilify is a partial blocker.

The intrinsic activity is the extent to which a ligand (ex. Abilify) activates dopamine receptors, and is expressed as a percentage. Dopamine's effect on dopamine receptors is by definition 100%. The intrinsic activity of Abilify is anywhere from 15 % - 60% depending on the receptor subpopulation in question (d2 long vs. d2 short). On postsynaptic receptors Abilify has low intrinsic activity, whereas on autoreceptors the intrinsic activity is high.

My Questions are:

How long after quitting Abilify will my ability to experience pleasure from Cannabis be restored to normal?

Has anyone else experienced the same? Please write about your experience.
 
Last edited:
Jbb79

Jbb79

ACCOUNT CLOSED
Joined
Sep 15, 2018
Messages
337
Location
Aalestrup --Dk
Abilify Nearly destroyed my life, I became more aggressive, on it - -

Abilify Made a bit Tired, I Guess that's the " Blocking " - Stuff x xx

I Got Hypersexuality side-effects, On 45 Mg, but it went away, With the pills . . .

To be Blunt, I Think it should take 2 - 6 days, if it's Pill-form, Injections Last longer, it might take 14 days, beyond last Effective dosage x xx

Abildfg3.jpg

Abi 3453.jpg

Abilify 566.jpg
 
Thread starter Similar threads Forum Replies Date
K Psychosis Forum 11
Top