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    Thread: World First Clinical Trial Supports Use of Kava to Treat Anxiety

    1. #1
      Senior Member firemonkee57's Avatar
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      Default World First Clinical Trial Supports Use of Kava to Treat Anxiety

      A world-first completed clinical study by an Australian team has found Kava, a medicinal South Pacific plant, significantly reduced the symptoms of people suffering anxiety.

      The study, led by the University of Melbourne and published in the Journal of Clinical Psychopharmacology, revealed Kava could be an alternative treatment to pharmaceutical products for the hundreds of thousands of Australians who suffer from Generalised Anxiety Disorders (GAD)

      Lead researcher, Dr Jerome Sarris from Department of Psychiatry at the University of Melbourne, said GAD is a complex condition that significantly affected people's day-today lives. Existing medications have a modest clinical effect and new effective options were needed for patients with anxiety. "Based on previous work we have recognised that plant based medicines may be a viable treatment for patients with chronic anxiety. In this study we've been able to show that Kava offers a potential natural alternative for the treatment of chronic clinical anxiety. Unlike some other options it has less risk of dependency and less potential for side effects," he said.

      The study also found that people's genetic differences (polymorphisms) of certain neurobiological mechanisms called GABA transporters, may modify their response to Kava. "If this finding is replicated, it may pave the way for simple genetic tests to determine which people may be likely to have a beneficial anxiety-reducing effect from taking Kava," Dr Sarris said.

      During the eight-week study, 75 patients with clinically diagnosed Generalised Anxiety Disorder were given Kava or placebo, and anxiety levels were regularly assessed. Results showed a significant reduction in anxiety for the Kava group compared to the placebo group at the end of the study.

      In participants diagnosed with moderate to severe GAD, Kava had an even greater effect in reducing anxiety. Following the completion of the controlled phase, 26 per cent of the Kava group were classified as in remission from their symptoms compared to six per cent of the placebo group.

      Participants in the Kava group were given tablets twice per day consisting of water-soluble extracted Kava (peeled rootstock) for a total dose of 120mg of kavalactones for the first three-week controlled phase. In cases of non-response this was increased to a double-dose twice per day for the second three-week controlled phase. Participants in the placebo group took matching dummy tablets in the same manner.

      Kava was also well tolerated. Results showed no significant differences across the two groups for liver function which had previously been a concern for Kava's medicinal use. In addition there were no considerable adverse reactions that could be attributed to Kava and no difference in withdrawal or addiction between the groups.

      An additional novel finding of the study, recently published in Phytotherapy Research was that Kava increased women's sex drive compared to those in the placebo group, believed to be due to the reduction of anxiety, rather than any aphrodisiac effect.

      Future studies confirming the genetic relationship to therapeutic response, and any libido-improving effects from Kava is now required. Dr Sarris said these significant findings are of importance to sufferers of anxiety and to the South Pacific region which relies on Kava as a major export.

      The study was funded by the NHMRC and Integria Healthcare who manufacture MediHerb and Thompson's Kava products.


      World first clinical trial supports use of Kava to treat anxiety

      Would have been better if the research had not been partially funded by a Kava manufacturer.
      My "newspaper" https://paper.li/f-1299495251
      Support mental health research http://www.mentalhealthresearchuk.org.uk/
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    2. #2
      Taff
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      Now if you had said Cava....

    3. #3
      Forum Guide Fairy Lucretia's Avatar
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      I thought that taffy!!
      I honestly did ,cava is champagne isn't it?
      it made me think of champagne
      xx
      which tbh I don't like ,I tried some once and I thought it would taste lovely but it tasted like stewed tea and old socks
      xx
      its nice to be important ,but its more important to be nice
      xxxx you count ,you matter ,you are important (I promise)

      Lucretia the fairy ,Magical fairy wonderland ,fairy hill kingdom ,po box whimsical folly land

    4. #4
      Taff
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      i had to google Kava, Lu and FM as it rang a bell but I couldn think what it was, I think its a pepper? FM will correct me as he knows lots !
      I am sure some police forces use it as a kind of restraint spray (Kava not Cava) I could be wrong?
      I know, Cava is like a champagne indeed.

    5. #5
      Taff
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      double post sorry

    6. #6
      Forum Guide Fairy Lucretia's Avatar
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      your new picture is cute taffy
      xx
      and firemonkee ,I don't understand your article ,sorry for the hijack
      its lovely of you to post intelligent stuff ,but that's not unusual
      xx
      its nice to be important ,but its more important to be nice
      xxxx you count ,you matter ,you are important (I promise)

      Lucretia the fairy ,Magical fairy wonderland ,fairy hill kingdom ,po box whimsical folly land

    7. #7
      Taff
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      Thanks Lu, thought i needed a new hat
      I just read this that FM posted
      Its for people with General anxiety Disorder and is supposed to be a new wonder drug but its from a plant.
      From a fast read of it, they tried it on 76 people, half on Kava and half on a placebo.
      So some of the half who took the Kava felt better on it.

      Not a lot of people to try it on I think? But as FM points out, the people who funded the study make Kava so not very impartial.
      A bit like Mr. Kellogg Funding a "cornflakes makes you feel good" trial

      They certainly wrote lots about it though (Kava that is) !

      hugs to you Lu xx and FM xx

    8. #8
      Forum Guide Fairy Lucretia's Avatar
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      hugs taffy ,fm and everyone
      xx
      its nice to be important ,but its more important to be nice
      xxxx you count ,you matter ,you are important (I promise)

      Lucretia the fairy ,Magical fairy wonderland ,fairy hill kingdom ,po box whimsical folly land

    9. #9
      Senior Member firemonkee57's Avatar
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      Yes, it's a type of pepper plant. Kava: The Amazing
      My "newspaper" https://paper.li/f-1299495251
      Support mental health research http://www.mentalhealthresearchuk.org.uk/
      http://mcpin.org/ https://www.mqmentalhealth.org/

    10. #10
      Taff
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      Gosh FM you need to set up a Kava business asap, (motto Kava is the new Cava) buying shares in this as I type.
      I have a strong urge to try this as a drink, seems that Southern Ireland isnt too happy about it.
      Realised this morning I got confused with Parva spray seriously important not to confuse them.
      It does look interesting though, I mean, look at the humble origins of asprin xx

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